Technology Process of .beta.-D-Gulopyranose, 3-amino-1,6-anhydro-3-deoxy-, 4-acetate 2-(dihydrogen phosphate)
There total 12 articles about .beta.-D-Gulopyranose, 3-amino-1,6-anhydro-3-deoxy-, 4-acetate 2-(dihydrogen phosphate) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; acetic acid;
under 2585.74 Torr;
DOI:10.1016/S0040-4020(99)00327-0
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: H2; aq. HCl / Pd/C / 2585.74 Torr
2.1: 70 percent / sodium carbonate / tetrahydrofuran; H2O
3.1: bis(tributyltin) oxide / toluene / 1.5 h / Heating
3.2: 96 percent / tetrabutylammonium bromide / toluene / 2.5 h / Heating
4.1: 88 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h
5.1: sodium hydroxide / ethanol; H2O / 0.33 h / Heating
6.1: dibutyltin oxide / toluene / 0.33 h / Heating
6.2: 1.29 g / tetrabutylammonium bromide / toluene / 0.25 h / Heating
7.1: 1H-tetrazole / CH2Cl2 / 0.67 h
8.1: 1.184 g / m-chloroperbenzoic acid / CH2Cl2; H2O / 0.08 h
9.1: 58 percent / aq. HCl / tetrahydrofuran / 48 h
10.1: 94 percent / pyridine / CH2Cl2 / 48 h
11.1: 94 percent / H2 / Pd/C / ethanol; acetic acid / 2585.74 Torr
With
pyridine; 1H-tetrazole; hydrogenchloride; sodium hydroxide; hydrogen; di(n-butyl)tin oxide; sodium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; bis(tri-n-butyltin)oxide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; toluene;
1.1: Reduction / 2.1: Acylation / 3.1: Esterification / 3.2: Alkylation / 4.1: Etherification / 5.1: Hydrolysis / 6.1: Condensation / 6.2: Alkylation / 7.1: phosphitylation / 8.1: Oxidation / 9.1: Hydrolysis / 10.1: Acetylation / 11.1: Hydrogenolysis;
DOI:10.1016/S0040-4020(99)00327-0
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: 15 percent / NaOMe / methanol
2.1: H2; aq. HCl / Pd/C / 2585.74 Torr
3.1: 70 percent / sodium carbonate / tetrahydrofuran; H2O
4.1: bis(tributyltin) oxide / toluene / 1.5 h / Heating
4.2: 96 percent / tetrabutylammonium bromide / toluene / 2.5 h / Heating
5.1: 88 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h
6.1: sodium hydroxide / ethanol; H2O / 0.33 h / Heating
7.1: dibutyltin oxide / toluene / 0.33 h / Heating
7.2: 1.29 g / tetrabutylammonium bromide / toluene / 0.25 h / Heating
8.1: 1H-tetrazole / CH2Cl2 / 0.67 h
9.1: 1.184 g / m-chloroperbenzoic acid / CH2Cl2; H2O / 0.08 h
10.1: 58 percent / aq. HCl / tetrahydrofuran / 48 h
11.1: 94 percent / pyridine / CH2Cl2 / 48 h
12.1: 94 percent / H2 / Pd/C / ethanol; acetic acid / 2585.74 Torr
With
pyridine; 1H-tetrazole; hydrogenchloride; sodium hydroxide; hydrogen; sodium methylate; di(n-butyl)tin oxide; sodium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; bis(tri-n-butyltin)oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; toluene;
1.1: Cyclization / 2.1: Reduction / 3.1: Acylation / 4.1: Esterification / 4.2: Alkylation / 5.1: Etherification / 6.1: Hydrolysis / 7.1: Condensation / 7.2: Alkylation / 8.1: phosphitylation / 9.1: Oxidation / 10.1: Hydrolysis / 11.1: Acetylation / 12.1: Hydrogenolysis;
DOI:10.1016/S0040-4020(99)00327-0
