3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

Base Information

Chemical Name:3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide
CAS No.:334513-11-0
Molecular Formula:C₆₇H₆₇N₃O₆
Molecular Weight:1010.29
Hs Code.:

3-(3,4-bis-benzyloxy-phenyl)-<i>N</i>-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-<i>N</i>-(4-dibenzylamino-butyl)-acrylamide

Synonyms:3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

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Chemical Property of 3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

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Technology Process of 3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

There total 7 articles about 3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 203571-41-9
3,4-dibenzyloxycinnamoyl chloride

: 334513-30-3
N-(3-amino-propyl)-N',N'-dibenzyl-butane-1,4-diamine

: 334513-11-0
3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 3h;
DOI:10.1016/S0040-4039(00)02308-X

Reference yield:

: 665782-46-7
4-[3-(trityl-amino)-propionylamino]-butyric acid

: 334513-11-0
3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: DCC / tetrahydrofuran; dimethylformamide / 12 h / 0 - 25 °C

2: NH₃; Et₃N / dimethylformamide / 3 h / 0 - 25 °C

3: LiAlH₄ / tetrahydrofuran / 48 h / Heating

4: 64 percent / Et₃N / CHCl₃ / 1.25 h / 0 - 25 °C

5: TFA / CH₂Cl₂ / 0.5 h / 25 °C

6: 70 percent / Et₃N / CH₂Cl₂ / 3 h / 0 - 25 °C

With lithium aluminium tetrahydride; ammonia; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)02308-X

Reference yield:

: C₂₉H₃₆N₂O₃Si

: 334513-11-0
3-(3,4-bis-benzyloxy-phenyl)-N-{3-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-N-(4-dibenzylamino-butyl)-acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1: methanol

2: DCC / tetrahydrofuran; dimethylformamide / 12 h / 0 - 25 °C

3: NH₃; Et₃N / dimethylformamide / 3 h / 0 - 25 °C

4: LiAlH₄ / tetrahydrofuran / 48 h / Heating

5: 64 percent / Et₃N / CHCl₃ / 1.25 h / 0 - 25 °C

6: TFA / CH₂Cl₂ / 0.5 h / 25 °C

7: 70 percent / Et₃N / CH₂Cl₂ / 3 h / 0 - 25 °C

With lithium aluminium tetrahydride; ammonia; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)02308-X