3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Base Information

Chemical Name:3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide
CAS No.:1393900-40-7
Molecular Formula:C₂₅H₂₇F₃N₆O
Molecular Weight:484.524
Hs Code.:

Synonyms:3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Suppliers and Price of 3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

There total 11 articles about 3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1393900-88-3
tert-butyl 3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

: 1393900-40-7
3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Guidance literature:: tert-butyl 3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate; With trifluoroacetic acid; In dichloromethane; at 35 ℃; for 2h; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With ammonium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 16155-03-6
1-methyl-4-(4-nitrophenyl)piperazine

: 1393900-40-7
3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.5 h / 150 °C / microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 2 h / 35 °C / Inert atmosphere

3.2: 20 h / 20 °C / Inert atmosphere

With hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1393900-40-7
3-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap / dichloromethane / 64 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 18 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / Dichlorofluoromethane / 16 h / 0 - 20 °C

7.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.5 h / 150 °C / microwave irradiation

8.1: trifluoroacetic acid / dichloromethane / 2 h / 35 °C / Inert atmosphere

8.2: 20 h / 20 °C / Inert atmosphere

With dmap; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; Dichlorofluoromethane; N,N-dimethyl-formamide;