1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane

Base Information

• Chemical Name: 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane
• CAS No.: 247575-39-9
• Molecular Formula: C₂₀H₂₄Br₂
• Molecular Weight: 424.219
• Mol file: 247575-39-9.mol

Synonyms:1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane

Chemical Property of 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane

There total 11 articles about 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,2-bis-(3'-hydroxymethyl-2',5'-dimethylphenyl)ethane (247575-38-8) → 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane (247575-39-9)

Guidance literature:

With hydrogen bromide; In water; benzene; for 36h; Heating;

DOI:10.1021/jo990721k

Reference yield:

2,4-dibromo-3,6-dimethylaniline (26829-89-0) → 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane (247575-39-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: conc. H₂SO₄; NaNO₂ / aq. ethanol; benzene

1.2: 75 percent / H₂SO₄ / H₂O; petroleum ether; benzene

2.1: 44 percent / dimethylformamide / 4 h / Heating

3.1: 97 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C

4.1: 100 percent / NaBH₄ / tetrahydrofuran / 20 h / 20 °C

5.1: 97 percent / 48 percent HBr / benzene; H₂O / 40 h / Heating

6.1: 93 percent / Mg; FeCl₃ / diethyl ether / 1 h / Heating

7.1: 96 percent / 1-methyl-pyrrolidin-2-one / 20 h / Heating

8.1: 82 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C

9.1: 95 percent / NaBH₄ / tetrahydrofuran / 24 h / 20 °C

10.1: 95 percent / 48 percent HBr / benzene; H₂O / 36 h / Heating

With sodium tetrahydroborate; sulfuric acid; hydrogen bromide; iron(III) chloride; diisobutylaluminium hydride; magnesium; sodium nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; benzene; 1.1: Diazotization / 1.2: Substitution / 2.1: Substitution / 3.1: Reduction / 4.1: Reduction / 5.1: Substitution / 6.1: Dimerization / 7.1: Substitution / 8.1: Reduction / 9.1: Reduction / 10.1: Substitution;

DOI:10.1021/jo990721k

Reference yield:

2,5-Dimethylaniline (95-78-3) → 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane (247575-39-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 94 percent / Br₂ / aq. ethanol; H₂O / 6 h / 20 °C

2.1: conc. H₂SO₄; NaNO₂ / aq. ethanol; benzene

2.2: 75 percent / H₂SO₄ / H₂O; petroleum ether; benzene

3.1: 44 percent / dimethylformamide / 4 h / Heating

4.1: 97 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C

5.1: 100 percent / NaBH₄ / tetrahydrofuran / 20 h / 20 °C

6.1: 97 percent / 48 percent HBr / benzene; H₂O / 40 h / Heating

7.1: 93 percent / Mg; FeCl₃ / diethyl ether / 1 h / Heating

8.1: 96 percent / 1-methyl-pyrrolidin-2-one / 20 h / Heating

9.1: 82 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C

10.1: 95 percent / NaBH₄ / tetrahydrofuran / 24 h / 20 °C

11.1: 95 percent / 48 percent HBr / benzene; H₂O / 36 h / Heating

With sodium tetrahydroborate; sulfuric acid; hydrogen bromide; bromine; iron(III) chloride; diisobutylaluminium hydride; magnesium; sodium nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; benzene; 1.1: Bromination / 2.1: Diazotization / 2.2: Substitution / 3.1: Substitution / 4.1: Reduction / 5.1: Reduction / 6.1: Substitution / 7.1: Dimerization / 8.1: Substitution / 9.1: Reduction / 10.1: Reduction / 11.1: Substitution;

DOI:10.1021/jo990721k

upstream raw materials:

1,2-bis-(3'-hydroxymethyl-2',5'-dimethylphenyl)ethane

2,4-dibromo-3,6-dimethylaniline

2,5-Dimethylaniline

2,6-dibromo-1,4-dimethylbenzene