Technology Process of 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane
There total 11 articles about 1,2-bis-(3'-bromomethyl-2',5'-dimethylphenyl)ethane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
In
water; benzene;
for 36h;
Heating;
DOI:10.1021/jo990721k
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: conc. H2SO4; NaNO2 / aq. ethanol; benzene
1.2: 75 percent / H2SO4 / H2O; petroleum ether; benzene
2.1: 44 percent / dimethylformamide / 4 h / Heating
3.1: 97 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C
4.1: 100 percent / NaBH4 / tetrahydrofuran / 20 h / 20 °C
5.1: 97 percent / 48 percent HBr / benzene; H2O / 40 h / Heating
6.1: 93 percent / Mg; FeCl3 / diethyl ether / 1 h / Heating
7.1: 96 percent / 1-methyl-pyrrolidin-2-one / 20 h / Heating
8.1: 82 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C
9.1: 95 percent / NaBH4 / tetrahydrofuran / 24 h / 20 °C
10.1: 95 percent / 48 percent HBr / benzene; H2O / 36 h / Heating
With
sodium tetrahydroborate; sulfuric acid; hydrogen bromide; iron(III) chloride; diisobutylaluminium hydride; magnesium; sodium nitrite;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; benzene;
1.1: Diazotization / 1.2: Substitution / 2.1: Substitution / 3.1: Reduction / 4.1: Reduction / 5.1: Substitution / 6.1: Dimerization / 7.1: Substitution / 8.1: Reduction / 9.1: Reduction / 10.1: Substitution;
DOI:10.1021/jo990721k
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 94 percent / Br2 / aq. ethanol; H2O / 6 h / 20 °C
2.1: conc. H2SO4; NaNO2 / aq. ethanol; benzene
2.2: 75 percent / H2SO4 / H2O; petroleum ether; benzene
3.1: 44 percent / dimethylformamide / 4 h / Heating
4.1: 97 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C
5.1: 100 percent / NaBH4 / tetrahydrofuran / 20 h / 20 °C
6.1: 97 percent / 48 percent HBr / benzene; H2O / 40 h / Heating
7.1: 93 percent / Mg; FeCl3 / diethyl ether / 1 h / Heating
8.1: 96 percent / 1-methyl-pyrrolidin-2-one / 20 h / Heating
9.1: 82 percent / DIBAL-H / hexane; benzene / 14 h / 20 °C
10.1: 95 percent / NaBH4 / tetrahydrofuran / 24 h / 20 °C
11.1: 95 percent / 48 percent HBr / benzene; H2O / 36 h / Heating
With
sodium tetrahydroborate; sulfuric acid; hydrogen bromide; bromine; iron(III) chloride; diisobutylaluminium hydride; magnesium; sodium nitrite;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; benzene;
1.1: Bromination / 2.1: Diazotization / 2.2: Substitution / 3.1: Substitution / 4.1: Reduction / 5.1: Reduction / 6.1: Substitution / 7.1: Dimerization / 8.1: Substitution / 9.1: Reduction / 10.1: Reduction / 11.1: Substitution;
DOI:10.1021/jo990721k