[1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R,S)]-

Base Information

Chemical Name:[1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R*,S*)]-
CAS No.:146335-31-1
Molecular Formula:C₃₉H₄₃NO₉
Molecular Weight:669.772
Hs Code.:
DSSTox Substance ID:DTXSID201099785

[1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R*,S*)]-

Synonyms:DTXSID201099785;[1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R*,S*)]-;146335-31-1

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R*,S*)]-

Chemical Property:

XLogP3:6.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:15
Exact Mass:669.29378195
Heavy Atom Count:49
Complexity:1000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C(C1=C(C=CC(=C1)C2=CC(=C(C=C2)OCC3=CC=CC=C3)C4OCCCO4)OCC5=CC=CC=C5)O)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H]([C@@H](C1=C(C=CC(=C1)C2=CC(=C(C=C2)OCC3=CC=CC=C3)C4OCCCO4)OCC5=CC=CC=C5)O)C(=O)OC

Technology Process of [1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R*,S*)]-

There total 33 articles about [1,1'-Biphenyl]-3-propanoic acid, alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-3'-(1,3-dioxan-2-yl)-beta-hydroxy-4,4'-bis(phenylmethoxy)-, methyl ester, [R-(R*,S*)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146335-30-0
4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

: 146335-31-1
3-(4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-yl)-2-tert-butoxycarbonylamino-3-hydroxy-propionic acid methyl ester

: 146335-31-1
4,4'-dibenzyloxy-3-<(R)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl

: 146335-31-1
4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Guidance literature:: With hydrogen; ((+)-(1R)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; In methanol; dichloromethane; at 50 ℃; for 72h; under 37503 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1055/s-1992-26351

Reference yield:

: 146335-30-0
4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

: 146335-31-1
3-(4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-yl)-2-tert-butoxycarbonylamino-3-hydroxy-propionic acid methyl ester

: 146335-31-1
4,4'-dibenzyloxy-3-<(R)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl

: 146335-31-1
4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Guidance literature:: With hydrogen; ((+)-(1R)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; In methanol; dichloromethane; at 50 ℃; for 72h; under 37503 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1055/s-1992-26351

Reference yield:

: 146335-30-0
4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl

: 146335-31-1
3-(4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-yl)-2-tert-butoxycarbonylamino-3-hydroxy-propionic acid methyl ester

: 146335-31-1
4,4'-dibenzyloxy-3-<(R)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl

: 146335-31-1
4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>-3'-(1,3-dioxan-2-yl)biphenyl

Guidance literature:: With hydrogen; ((+)-(1R)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; In methanol; dichloromethane; at 50 ℃; for 72h; under 37503 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1055/s-1992-26351