2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

Base Information

Chemical Name:2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide
CAS No.:301685-63-2
Molecular Formula:C₃₁H₄₃N₃O₅
Molecular Weight:537.7
Hs Code.:

Synonyms:2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

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Chemical Property of 2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

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Technology Process of 2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

There total 3 articles about 2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 301685-63-2
2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

Guidance literature:

Reference yield:

: 301685-23-4
(2R)-2-({formyl[(phenylmethyl)oxy]amino}methyl)hexanoic acid

: 301685-62-1
2(S)-amino-3,3-dimethyl-1-(4-morpholin-4-ylphenyl)-butan-1-one

: 301685-63-2
2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2003.10.013

Reference yield:

: 301685-61-0
[2,2-dimethyl-1(S)-(4-morpholin-4-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester

: 301685-63-2
2(R)-[(N-benzyloxy-N-formylamino)-methyl]-hexanoic acid-[2',2'-dimethyl-(1'(S)-4-morpholin-4-ylbenzoyl)-propyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 20 °C

2: EDC; HOBt / dimethylformamide / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.10.013