(3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

Base Information

Chemical Name:(3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid
CAS No.:177769-64-1
Molecular Formula:C₁₈H₂₇NO₅
Molecular Weight:337.416
Hs Code.:

(3S,4S,5S)-4-<Benzyloxycarbonyl(methyl)amino>-3-methoxy-5-methylheptanoic acid

Synonyms:(3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

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Chemical Property of (3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

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Technology Process of (3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

There total 2 articles about (3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: [(1S,2S)-1-((S)-sec-Butyl)-4-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-2-methoxy-4-oxo-butyl]-methyl-carbamic acid benzyl ester

: 177769-64-1
(3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1039/p19960000853

Reference yield:

: (3S,4S,5S)-4-(Benzyloxycarbonyl-methyl-amino)-3-methoxy-5-methyl-heptanoic acid methyl ester

: 177769-64-1
(3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 3h; Ambient temperature;
DOI:10.1248/cpb.43.1706

Reference yield:

: 177769-64-1
(3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid

: 130272-98-9
(S)-N-{(S)-1-[((1S,2S)-1-((S)-sec-Butyl)-2-methoxy-4-{(S)-2-[(1R,2R)-1-methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidin-1-yl}-4-oxo-butyl)-methyl-carbamoyl]-2-methyl-propyl}-2-dimethylamino-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: H₂SO₄ / CH₂Cl₂

2: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

3: 1,3-dicyclohexylcarbodiimide / acetonitrile / a) 0 deg C, 3 h, b) RT, 16 h

4: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

5: diethyl phosphorocyanidate, Et₃N / dimethylformamide / a) 0 deg C, 4 h, b) RT, 16 h

6: trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

7: diethyl phosphorocyanidate, Et₃N / dimethylformamide / a) 0 deg C, 2 h, b) RT, 16 h

With diethyl cyanophosphonate; sulfuric acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706