3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

Base Information

Chemical Name:3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone
CAS No.:205178-26-3
Molecular Formula:C₁₉H₁₄Cl₃NO₅S
Molecular Weight:474.749
Hs Code.:

Synonyms:3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

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Chemical Property of 3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

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Technology Process of 3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

There total 5 articles about 3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 205178-24-1
3-chloro-2,6-dimethoxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

: 205178-26-3
3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

Guidance literature:: With boron tribromide; In n-heptane; dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo972340h

Reference yield:

: 38064-90-3
2,4-dimethoxytoluene

: 205178-26-3
3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 76 percent / N-chlorosuccinimide / dimethylformamide / 2 h / Heating

2.1: n-butyllithium / diethyl ether; hexane / 0.67 h / 20 °C

2.2: 69 percent / diethyl ether; hexane / 0.67 h / ice/salt cooling

3.1: 60 percent / N-chlorosuccinimide / tetrahydrofuran / Heating

4.1: 69 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

5.1: 66 percent / BBr₃ / CH₂Cl₂; heptane / 24 h / 20 °C

With N-chloro-succinimide; n-butyllithium; boron tribromide; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; hexane; n-heptane; dichloromethane; N,N-dimethyl-formamide; 1.1: Chlorination / 2.1: Metallation / 2.2: Addition / 3.1: Chlorination / 4.1: Oxidation / 5.1: demethylation;
DOI:10.1021/jo972340h

Reference yield:

: 85034-00-0
1-chloro-2,4-dimethoxy-5-methylbenzene

: 205178-26-3
3-chloro-2,6-dihydroxy-5-methylphenyl 2,5-dichloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl ketone

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.67 h / 20 °C

1.2: 69 percent / diethyl ether; hexane / 0.67 h / ice/salt cooling

2.1: 60 percent / N-chlorosuccinimide / tetrahydrofuran / Heating

3.1: 69 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

4.1: 66 percent / BBr₃ / CH₂Cl₂; heptane / 24 h / 20 °C

With N-chloro-succinimide; n-butyllithium; boron tribromide; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; hexane; n-heptane; dichloromethane; 1.1: Metallation / 1.2: Addition / 2.1: Chlorination / 3.1: Oxidation / 4.1: demethylation;
DOI:10.1021/jo972340h