3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 468096-31-3
• Molecular Formula: C₂₁H₂₄ClN₃OS₂
• Molecular Weight: 434.026
• Mol file: 468096-31-3.mol

Synonyms:3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property of 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one

There total 4 articles about 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-chloroethylpiperidine hydrochloride (2008-75-5) + 3-(4-chlorophenyl)-2-mercapto-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one (126105-97-3) → 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one (468096-31-3)

Guidance literature:

With sodium hydroxide; In water; at 50 ℃; for 0.5h;

DOI:10.1211/0022357021778871

Reference yield:

4-Chlorophenyl isothiocyanate (2131-55-7) → 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one (468096-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / ethanol / 2 h / Heating

2: 85 percent / KOH / H₂O / 1 h / Heating

3: 85 percent / NaOH / H₂O / 0.5 h / 50 °C

With potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1211/0022357021778871

Reference yield:

2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester (4815-24-1) → 3-(4-chlorophenyl)-5,6-dimethyl-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one (468096-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / ethanol / 2 h / Heating

2: 85 percent / KOH / H₂O / 1 h / Heating

3: 85 percent / NaOH / H₂O / 0.5 h / 50 °C

With potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1211/0022357021778871

upstream raw materials:

N-chloroethylpiperidine hydrochloride

3-(4-chlorophenyl)-2-mercapto-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one

4-Chlorophenyl isothiocyanate

2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester