Technology Process of 1-[2,3-dideoxy-3,3-difluoro-4-thio-5-O-toluoyl-β-L-ribofuranosyl]-N4-benzoyl-5-fluorocytosine
There total 7 articles about 1-[2,3-dideoxy-3,3-difluoro-4-thio-5-O-toluoyl-β-L-ribofuranosyl]-N4-benzoyl-5-fluorocytosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-benzoyl-5-fluorocytosine; 1-O-acetyl-2,3-dideoxy-3,3-difluoro-4-thio-5-O-toluoyl-L-furanose;
With
N,O-bis-(trimethylsilyl)-acetamide;
In
acetonitrile;
at 50 - 60 ℃;
for 2h;
With
trimethylsilyl trifluoromethanesulfonate;
In
acetonitrile;
for 3h;
Heating;
DOI:10.1021/jm0303148
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 73 percent / pyridinium dichromate; molecular sieves 4 Angstroem / CH2Cl2 / 4 h / 20 °C
2.1: 55 percent / (diethylamino)sulfur trifluoride / CH2Cl2 / 24 h / 20 °C
3.1: 94 percent / boron trifluoride etherate / CH2Cl2 / 2 h / 40 °C
4.1: 2,6-lutidine / CH2Cl2 / 0.92 h / -10 - 0 °C
5.1: 27.6 g / BaCO3; n-TBAI / 3 h / 50 - 60 °C
6.1: 72 percent / acetic acid; mercuric acetate / 24 h / 20 °C
7.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 2 h / 50 - 60 °C
7.2: 32 percent / TMSOTf / acetonitrile / 3 h / Heating
With
2,6-dimethylpyridine; dipyridinium dichromate; N,O-bis-(trimethylsilyl)-acetamide; diethylamino-sulfur trifluoride; 4 A molecular sieve; boron trifluoride diethyl etherate; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; acetic acid; barium carbonate;
In
dichloromethane; acetonitrile;
DOI:10.1021/jm0303148
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 55 percent / (diethylamino)sulfur trifluoride / CH2Cl2 / 24 h / 20 °C
2.1: 94 percent / boron trifluoride etherate / CH2Cl2 / 2 h / 40 °C
3.1: 2,6-lutidine / CH2Cl2 / 0.92 h / -10 - 0 °C
4.1: 27.6 g / BaCO3; n-TBAI / 3 h / 50 - 60 °C
5.1: 72 percent / acetic acid; mercuric acetate / 24 h / 20 °C
6.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 2 h / 50 - 60 °C
6.2: 32 percent / TMSOTf / acetonitrile / 3 h / Heating
With
2,6-dimethylpyridine; N,O-bis-(trimethylsilyl)-acetamide; diethylamino-sulfur trifluoride; boron trifluoride diethyl etherate; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; acetic acid; barium carbonate;
In
dichloromethane; acetonitrile;
DOI:10.1021/jm0303148
