5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine

Base Information

• Chemical Name: 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine
• CAS No.: 357928-51-9
• Molecular Formula: C₂₃H₂₆N₆O₆
• Molecular Weight: 482.496

Synonyms:5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine

Chemical Property of 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine

There total 2 articles about 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-((benzyloxy)carbonyl)-3-methylimidazolium tetrafluoroborate + 5'-deoxy-5'-acetamido-2',3'-O-isopropylidene adenosine (32077-99-9) → 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N6-[phenylmethoxycarbonyl]adenosine (357928-51-9)

Guidance literature:

In dichloromethane; acetonitrile; at 20 ℃; for 20h;

DOI:10.1021/ol015995k

Reference yield:

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine (21950-36-7) → 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N6-[phenylmethoxycarbonyl]adenosine (357928-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine / 0 - 20 °C

2: 92 percent / CH₂Cl₂; acetonitrile / 20 h / 20 °C

With pyridine; In dichloromethane; acetonitrile;

DOI:10.1021/ol015995k

Reference yield: 50.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N6-[phenylmethoxycarbonyl]adenosine (357928-51-9) → 3-{Acetyl-[(3aR,4R,6R,6aR)-6-(6-benzyloxycarbonylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-amino}-3-oxo-propionic acid methyl ester (357928-53-1)

Guidance literature:

In toluene; Heating;

DOI:10.1021/ol015995k

upstream raw materials:

5'-deoxy-5'-acetamido-2',3'-O-isopropylidene adenosine

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

Downstream raw materials:

3-{Acetyl-[(3aR,4R,6R,6aR)-6-(6-benzyloxycarbonylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-amino}-3-oxo-propionic acid methyl ester

3-{Acetyl-[(3aR,4R,6R,6aR)-6-(6-benzyloxycarbonylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-amino}-2-diazo-3-oxo-propionic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 357928-51-9 5'-acetamido-5'-deoxy-2',3'-isopropylidene-N⁶-[phenylmethoxycarbonyl]adenosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send