2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

Base Information

Chemical Name:2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester
CAS No.:1374779-91-5
Molecular Formula:C₂₂H₂₀ClNO₃SSi
Molecular Weight:442.01
Hs Code.:

Synonyms:2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

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Chemical Property of 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

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Technology Process of 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

There total 3 articles about 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1374779-17-5
methyl 4-bromo-2-[(3-chloro-benzo[b]thiophene-2-carboxamido)]benzoate

: 1066-54-2
trimethylsilylacetylene

: 1374779-91-5
2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

Guidance literature:: With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; at 100 ℃; for 1h; Microwave;

Reference yield:

: 135484-83-2
2-amino-4-bromo-benzoic acid methyl ester

: 1374779-91-5
2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 20 °C

2: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 1 h / 100 °C / Microwave

With pyridine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;

Reference yield:

: 158580-57-5
methyl 4-bromo-2-nitrobenzoate

: 1374779-91-5
2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-trimethylsilanylethynylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 30 °C / Ultrasonic irradiation

2: pyridine / tetrahydrofuran / 20 °C

3: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 1 h / 100 °C / Microwave

With pyridine; copper(l) iodide; tin(II) chloride dihdyrate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethyl acetate;