(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Base Information

Chemical Name:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CAS No.:1196541-47-5
Molecular Formula:C₁₆H₂₀BrN₅O
Molecular Weight:378.272
Hs Code.:
Mol file:1196541-47-5.mol

Synonyms:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Suppliers and Price of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GDC0575（ARRY-575，RG7441） >98%
5 mg
$ 350.00

DC Chemicals
GDC0575（ARRY-575，RG7441） >98%
10 mg
$ 500.00

ChemScene
GDC-0575 99.50%
100mg
$ 2100.00

ChemScene
GDC-0575 99.50%
50mg
$ 1200.00

ChemScene
GDC-0575 99.50%
25mg
$ 720.00

ChemScene
GDC-0575 99.50%
10mg
$ 360.00

ChemScene
GDC-0575 99.50%
5mg
$ 210.00

Total 11 raw suppliers

Chemical Property of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Chemical Property:

PKA:14.25±0.40(Predicted)
Density:1.619±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

GDC0575（ARRY-575，RG7441） >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

There total 5 articles about (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1196508-04-9
(R)-5-bromo-4-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-(cyclopropanecarboxamido)-1H-pyrrolo[2,3-b]pyridine

: 1196541-47-5
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Guidance literature:: With sulfuric acid; In tetrahydrofuran; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1477532-48-1
5-bromo-4-chloro-3-nitro-1H-pyrrolo[2,3-b]pyridine

: 1196541-47-5
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / tert-Amyl alcohol / 48 h / 85 °C / Inert atmosphere

2: hydrogen; 4-methyl-morpholine; 1 % platinum and 2% vanadium on carbon / 2-methyltetrahydrofuran / 50 °C / 3750.38 Torr

3: 2-methyltetrahydrofuran / 1.17 h / 15 - 25 °C

4: sulfuric acid / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

With 4-methyl-morpholine; sulfuric acid; 1 % platinum and 2% vanadium on carbon; hydrogen; In tetrahydrofuran; 2-methyltetrahydrofuran; tert-Amyl alcohol;

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1196541-47-5
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / tert-Amyl alcohol / 48 h / 85 °C / Inert atmosphere

2: hydrogen; 4-methyl-morpholine; 1 % platinum and 2% vanadium on carbon / 2-methyltetrahydrofuran / 50 °C / 3750.38 Torr

3: 2-methyltetrahydrofuran / 1.17 h / 15 - 25 °C

4: sulfuric acid / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

With 4-methyl-morpholine; sulfuric acid; 1 % platinum and 2% vanadium on carbon; hydrogen; In tetrahydrofuran; 2-methyltetrahydrofuran; tert-Amyl alcohol;