(1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

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Chemical Name:(1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester
CAS No.:849596-67-4
Molecular Formula:C₂₁H₂₄O₅S
Molecular Weight:388.485
Hs Code.:

Synonyms:(1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

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Chemical Property of (1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

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Technology Process of (1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

There total 4 articles about (1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 849596-65-2
(1S,2R,1'S)-2-(2-hydroxy-1-phenyl-ethoxy)-cyclohex-3-enol

: 98-59-9
p-toluenesulfonyl chloride

: 849596-67-4
(1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

Guidance literature:: With dmap; TEA; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/j.tet.2005.01.003

Reference yield:

: 849596-59-4
(1S,3S,4R)-3-phenyl-4a,7,8,8a-tetrahydro-benzo[1,4]dioxin-2-one

: 849596-67-4
(1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaBH₄ / 1,2-dimethoxy-ethane / 1 h / 20 °C

2: 93 percent / TEA; DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; sodium tetrahydroborate; TEA; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/j.tet.2005.01.003

Reference yield:

: 849596-58-3
(1S,3S,4S,5S)-3-phenyl-5-phenylselenyl-hexahydro-benzo[1,4]dioxin-2-one

: 849596-67-4
(1S,2R,1'S)-toluene-4-sulfonic acid 2-(6-hydroxy-cyclohex-2-enyloxy)-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaIO₄ / methanol; H₂O / 20 °C

2: 0.5 g / CCl₄ / 5 h / 70 °C

3: 77 percent / NaBH₄ / 1,2-dimethoxy-ethane / 1 h / 20 °C

4: 93 percent / TEA; DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; sodium tetrahydroborate; sodium periodate; TEA; In methanol; tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.tet.2005.01.003