3-amino-5-oxo-N-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

Base Information

Chemical Name:3-amino-5-oxo-N-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide
CAS No.:663218-08-4
Molecular Formula:C₁₉H₁₄F₃N₃O₂S
Molecular Weight:405.4
Hs Code.:
Mol file:663218-08-4.mol

Synonyms:3-amino-5-oxo-N-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

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Chemical Property of 3-amino-5-oxo-N-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

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Technology Process of 3-amino-5-oxo-N-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

There total 4 articles about 3-amino-5-oxo-N-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 25625-57-4
2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide

: 165283-98-7
5-oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

: 663218-08-4
3-amino-5-oxo-N-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

Guidance literature:: With sodium carbonate; In ethanol; for 18h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2014.09.001

Reference yield:

: 504-02-9
1,3-cylohexanedione

: 663218-08-4
3-amino-5-oxo-N-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: sodium carbonate / ethanol / 18 h / Inert atmosphere; Reflux

With sodium hydride; sodium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.09.001

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 663218-08-4
3-amino-5-oxo-N-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.25 h / 0 °C / Inert atmosphere

2: sodium carbonate / ethanol / 18 h / Inert atmosphere; Reflux

With sodium carbonate; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.09.001