N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine

Base Information

• Chemical Name: N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine
• CAS No.: 121587-42-6
• Molecular Formula: C₂₅H₂₈F₃NO₆
• Molecular Weight: 495.496
• Mol file: 121587-42-6.mol

Synonyms:N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine

Chemical Property of N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine

There total 20 articles about N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-trifluoroacetyl-2-<2-<(4R,5R)-5-benzyloxymethyl-1,3-dioxolan-4-yl>-1-hydroxymethyl-3-methoxyphenyl>ethylamine (121587-41-5,121652-67-3) → N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine (121587-42-6)

Guidance literature:

With dipyridine chromium trioxide; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)82331-X

Reference yield: 84.0%

N-(2-{2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-methoxy-phenyl}-ethyl)-2,2,2-trifluoro-acetamide (121587-41-5,121652-67-3) → N-{2-[2-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carbonyl)-3-methoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide (121587-42-6)

Guidance literature:

With dipyridine chromium trioxide; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)82331-X

Reference yield:

N-trifluoroacetyl-2-(2-bromo-3-methoxyphenyl)ethylamine (121587-40-4) → N-trifluoroacetyl-2-<2-<(4S,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-carbonyl>-3-methoxyphenyl>ethylamine (121587-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / hexane; diethyl ether / 1 h / -78 °C

2: pyridine, chromium (III) oxide, celite / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; chromium(III) oxide; n-butyllithium; Celite; In diethyl ether; hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)80641-4

upstream raw materials:

N-trifluoroacetyl-2-<2-<(4R,5R)-5-benzyloxymethyl-1,3-dioxolan-4-yl>-1-hydroxymethyl-3-methoxyphenyl>ethylamine

2-bromo-3-methylanisole

N-trifluoroacetyl-2-(2-bromo-3-methoxyphenyl)ethylamine

2-bromo-1-(bromomethyl)-3-methoxybenzene

Downstream raw materials:

(1S,10bS)-1-((S)-2-Benzyloxy-1-hydroxy-ethyl)-10-methoxy-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

(R)-1-((E)-3-Benzyloxy-propenyl)-8-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

(R)-1-(2-Hydroxy-ethyl)-8-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

(R)-8-Methoxy-1-vinyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester