tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate

Base Information

• Chemical Name: tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate
• CAS No.: 105259-82-3
• Molecular Formula: C₃₉H₅₅N₃O₇
• Molecular Weight: 677.882
• Mol file: 105259-82-3.mol

Synonyms:tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate

Chemical Property of tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate

There total 6 articles about tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-oxohexanoate (99198-61-5) + N-(L-alanyl)-N-(2-indanyl)glycine tert-butyl ester oxalate (108428-37-1) → tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate (105259-81-2) + tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate (105259-82-3)

Guidance literature:

With 3 A molecular sieve; sodium acetate; sodium cyanoborohydride; acetic acid; In ethanol;

DOI:10.1248/cpb.42.580

Reference yield:

diethyl cyanophosphonate (2942-58-7) + tert-butyl N-(2,3-dihydro-1H-inden-2-yl)glycinate (83402-63-5) + N-<(1S)-5-(1-benzyloxycarbonyl-4-piperidyl)-1-ethoxycarbonylpentyl>-L-alanine → tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate (105259-82-3)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl-N-<(1S)-5-(1-benzyloxycarbonyl-4-piperidyl)-1-ethoxycarbonylpentyl>-L-alaninate (105259-97-0) → tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate (105259-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 5 N HCl / ethyl acetate / 4 h

2: 1.) diethyl phosphorocyanidate (DEPC), 2.) Et₃N / 1.) DMF, 30 min, 2.) DMF, a) 0 deg C, 30 min, b) RT, 30 min

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In ethyl acetate;

DOI:10.1248/cpb.42.580

upstream raw materials:

ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-oxohexanoate

N-(L-alanyl)-N-(2-indanyl)glycine tert-butyl ester oxalate

tert-butyl-N-<(1S)-5-(1-benzyloxycarbonyl-4-piperidyl)-1-ethoxycarbonylpentyl>-L-alaninate

ethyl (2R)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate