2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Base Information

Chemical Name:2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide
CAS No.:864494-46-2
Molecular Formula:C₂₀H₂₀N₄OS
Molecular Weight:364.471
Hs Code.:
DSSTox Substance ID:DTXSID801131525
ChEMBL ID:CHEMBL1669784

Synonyms:SCHEMBL1940705;CHEMBL1669784;OQUFIAIDSYNHJN-UHFFFAOYSA-N;DTXSID801131525;2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide;2-[[(2-Amino-4-pyridinyl)methyl]thio]-N-(3,5-dimethylphenyl)-3-pyridinecarboxamide;864494-46-2

Suppliers and Price of 2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:364.13578245
Heavy Atom Count:26
Complexity:453

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)NC(=O)C2=C(N=CC=C2)SCC3=CC(=NC=C3)N)C

Technology Process of 2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

There total 4 articles about 2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 754219-11-9
N-(3,5-dimethylphenyl)-2-thioxo-1,2-dihydropyridine-3-carboxamide

: 864461-13-2
4-(bromomethyl)pyridin-2-amine hydrobromide

: 864494-46-2
2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

Reference yield:

: 38521-46-9
3-carboxy-2-mercaptopyridine

: 864494-46-2
2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 20 °C / Cooling with ice

1.2: 0.67 h / 20 °C

2.1: water; N,N-dimethyl-formamide / 16 h / 60 °C

3.1: triethylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.071

Reference yield:

: C₁₀H₇N₃O₃S

: 864494-46-2
2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; N,N-dimethyl-formamide / 16 h / 60 °C

2: triethylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.071