(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

Base Information

Chemical Name:(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one
CAS No.:436145-76-5
Molecular Formula:C₂₄H₂₉NO₅S
Molecular Weight:443.564
Hs Code.:

Synonyms:(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

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Chemical Property of (S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

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Technology Process of (S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

There total 7 articles about (S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 436861-56-2
(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-ol

: 436145-76-5
(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol0258482

Reference yield:

4-ethynylveratrole: 4302-52-7
4-ethynylveratrole

: 436145-76-5
(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / CHCl₃ / 3.5 h / Irradiation

2.1: m-chloroperbenzoic acid; potassium carbonate / CH₂Cl₂ / 20 °C

2.2: 85 percent / CHCl₃ / 5 h / Heating

3.1: 94 mg / methanol / 4 h / Heating

4.1: 53 percent / n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.02 h / -78 °C

5.1: 95 percent / sodium borohydride / methanol / 1 h / 20 °C

6.1: 65 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 6.1: Swern oxidation;
DOI:10.1021/ol0258482

Reference yield:

: 68819-94-3
p-tolyl benzeneselenosulfonate

: 436145-76-5
(S)-4-(3,4-Dimethoxy-phenyl)-3-(toluene-4-sulfonyl)-octahydro-quinolizin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / CHCl₃ / 3.5 h / Irradiation

2.1: m-chloroperbenzoic acid; potassium carbonate / CH₂Cl₂ / 20 °C

2.2: 85 percent / CHCl₃ / 5 h / Heating

3.1: 94 mg / methanol / 4 h / Heating

4.1: 53 percent / n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.02 h / -78 °C

5.1: 95 percent / sodium borohydride / methanol / 1 h / 20 °C

6.1: 65 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 6.1: Swern oxidation;
DOI:10.1021/ol0258482