2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide

Base Information

• Chemical Name: 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide
• CAS No.: 1356165-38-2
• Molecular Formula: C₁₇H₂₈BrClO₂Si
• Molecular Weight: 407.851
• Mol file: 1356165-38-2.mol

Synonyms:2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide

Chemical Property of 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide

There total 3 articles about 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl alcohol (1356165-41-7) → 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide (1356165-38-2)

Guidance literature:

With pyridine; phosphorus tribromide; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/ejoc.201101183

Reference yield:

4-methoxy-3-(triisopropylsilyloxy)benzyl alcohol (1356165-40-6) → 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide (1356165-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / chloroform / 0 - 20 °C / Inert atmosphere

2: pyridine; phosphorus tribromide / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With pyridine; sulfuryl dichloride; phosphorus tribromide; In dichloromethane; chloroform;

DOI:10.1002/ejoc.201101183

Reference yield:

4-methoxy-3-(triisopropylsilyloxy)-benzaldehyde (179260-96-9) → 2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl bromide (1356165-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Inert atmosphere

2: sulfuryl dichloride / chloroform / 0 - 20 °C / Inert atmosphere

3: pyridine; phosphorus tribromide / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; sulfuryl dichloride; phosphorus tribromide; In ethanol; dichloromethane; chloroform;

DOI:10.1002/ejoc.201101183

upstream raw materials:

4-methoxy-3-(triisopropylsilyloxy)benzyl alcohol

2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl alcohol

4-methoxy-3-(triisopropylsilyloxy)-benzaldehyde

Downstream raw materials:

1-[2-chloro-4-methoxy-5-(triisopropylsilyloxy)benzyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline