2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione
CAS No.:1417526-19-2
Molecular Formula:C₃₀H₂₉F₃N₄O₃
Molecular Weight:550.58
Hs Code.:

Synonyms:2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

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Chemical Property of 2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

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Technology Process of 2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

There total 7 articles about 2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417526-18-1
C₂₀H₂₃F₃N₂

: 2-(1,3-dioxoisoindolin-2-yl)-N-hydroxyacetimidoyl chloride

: 1417526-19-2
2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

Guidance literature:: 2-(1,3-dioxoisoindolin-2-yl)-N-hydroxyacetimidoyl chloride; With triethylamine; In tetrahydrofuran; for 0.333333h; Cooling with ice; Inert atmosphere;

C₂₀H₂₃F₃N₂; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 172410-34-3
2-(1,3-dioxoisoindolin-2-yl)acetaldehyde oxime

: 1417526-19-2
2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice; Inert atmosphere

2.2: 2 h / 20 °C

With N-chloro-succinimide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1417526-19-2
2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Inert atmosphere; Reflux

2.1: dichloromethane / 2 h / Molecular sieve; Reflux

3.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice; Inert atmosphere

3.2: 2 h / 20 °C

With palladium diacetate; sodium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;