5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil
CAS No.:174221-82-0
Molecular Formula:C₃₂H₂₈Cl₃N₃O₇
Molecular Weight:672.949
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Suppliers and Price of 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 545-06-2
trichloroacetonitrile

: 173170-12-2
2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil

: 174221-82-0
5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Guidance literature:: With triethylamine; at 90 ℃;
DOI:10.1016/0040-4039(96)00227-4

Reference yield:

: 3736-77-4
2,2'-Anhydrouridine

: 174221-82-0
5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / DMAP / pyridine / 16 h / Ambient temperature

2: 43 percent / NaH / 16 h / 90 °C

With dmap; sodium hydride; In pyridine;
DOI:10.1021/jo9510548

Reference yield:

: 58-96-8
uridine

: 174221-82-0
5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / diphenyl carbonate, sodium bicarbonate / dimethylformamide / 4.5 h / 110 - 120 °C

2: 56 percent / DMAP / pyridine / 16 h / Ambient temperature

3: 43 percent / NaH / 16 h / 90 °C

With bis(phenyl) carbonate; dmap; sodium hydride; sodium hydrogencarbonate; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo9510548