1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

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Chemical Name:1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea
CAS No.:1608091-94-6
Molecular Formula:C₂₁H₂₁F₆N₃S
Molecular Weight:461.474
Hs Code.:

Synonyms:1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

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Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

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Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

There total 9 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1608091-97-9
(S)-2-((S)-azido(phenyl)methyl)pyrrolidine

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1608091-94-6
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1021/acs.orglett.7b01000

Reference yield:

: 850265-25-7
[(S)-[(2S)-(1-methyl-2-pyrrolidinyl)]phenylmethyl]amine

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1608091-94-6
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

Guidance literature:: In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.tetasy.2014.02.011

Reference yield:

: 1608091-96-8
(S)-2-((S)-azido(phenyl)methyl)-1-tritylpyrrolidine

: 1608091-94-6
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((S)-1-methylpyrrolidin-2-yl)(phenyl)methyl)thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / diethyl ether / 3 h / 20 °C

2: formic acid / water / 3 h / 100 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice; Inert atmosphere

4: dichloromethane / 18 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; formic acid; water; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/j.tetasy.2014.02.011