di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Base Information

Chemical Name:di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate
CAS No.:913542-70-8
Molecular Formula:C₃₆H₅₂N₄O₈
Molecular Weight:668.831
Hs Code.:

Synonyms:di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

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Chemical Property of di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

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Technology Process of di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

There total 5 articles about di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 913542-69-5
di-tert-butyl-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

: 5437-45-6
Benzyl bromoacetate

: 913542-70-8
di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Guidance literature:: With potassium carbonate; In acetonitrile;
DOI:10.1016/j.tetlet.2006.07.135

Reference yield: 87.0%

: 13139-12-3
tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate

: 294-90-6
1,4,7,10-tetraazacyclododecan

: 5437-45-6
Benzyl bromoacetate

: 913542-70-8
di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Guidance literature:: tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate; 1,4,7,10-tetraazacyclododecan; In chloroform; at 20 ℃; for 28h; Inert atmosphere;

Benzyl bromoacetate; With potassium carbonate; In acetonitrile; for 8h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2017.06.008

Reference yield:

: 13139-12-3
tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate

: 913542-70-8
di-tert-butyl 4-[2-(benzyloxy)-2-oxoethyl]-10-[2-(benzyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CHCl₃ / 20 °C

2: 93 percent / K₂CO₃ / acetonitrile

With potassium carbonate; In chloroform; acetonitrile;
DOI:10.1016/j.tetlet.2006.07.135