5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol

Base Information

• Chemical Name: 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol
• CAS No.: 1322089-38-2
• Molecular Formula: C₁₅H₁₂BrF₂NO
• Molecular Weight: 340.167
• Mol file: 1322089-38-2.mol

Synonyms:5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol

Chemical Property of 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol

There total 3 articles about 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-bromo-1-methyl-2-phenyl-1H-indole (1013932-68-7) → 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol (1322089-38-2)

Guidance literature:

With water; sodium hydrogencarbonate; Selectfluor; In acetonitrile; at 0 ℃; for 1h;

DOI:10.1021/ol201896p

Reference yield:

phenylacetylene (536-74-3) → 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol (1322089-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 40 °C

2: silver nitrate / acetonitrile / 12 h / 80 °C

3: Selectfluor; water / 0.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; silver nitrate; Selectfluor; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1039/c3cc49851d

Reference yield:

4-bromo-N-methyl-2-(phenylethynyl)aniline (1570216-19-1) → 5-bromo-3,3-difluoro-1-methyl-2-phenylindolin-2-ol (1322089-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: silver nitrate / acetonitrile / 12 h / 80 °C

2: Selectfluor; water / 0.5 h / 0 °C

With water; silver nitrate; Selectfluor; In acetonitrile;

DOI:10.1039/c3cc49851d

upstream raw materials:

5-bromo-1-methyl-2-phenyl-1H-indole

4-bromo-N-methyl-2-(phenylethynyl)aniline

phenylacetylene