C₃₂H₃₃INO₅PS

Base Information

• Chemical Name: C₃₂H₃₃INO₅PS
• CAS No.: 257299-99-3
• Molecular Formula: C₃₂H₃₃INO₅PS
• Molecular Weight: 701.562
• Mol file: 257299-99-3.mol

Synonyms:C₃₂H₃₃INO₅PS

Chemical Property of C₃₂H₃₃INO₅PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₃INO₅PS

There total 11 articles about C₃₂H₃₃INO₅PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-3,5-dimethoxybenzene (7051-16-3) → C32H33INO5PS (257299-99-3)

Guidance literature:

Multi-step reaction with 11 steps

1.1: Mg; BrCH₂CH₂Br / tetrahydrofuran / 10 h / Heating

1.2: 92 percent / CuBr*SMe₂ / tetrahydrofuran / 4.5 h / -20 °C

2.1: 88 percent / PPh₃; DEAD / tetrahydrofuran / 20 h / 0 - 20 °C

3.1: 89 percent / H₂NNH₂ / ethanol / 7 h / Heating

4.1: 99 percent / NEt₃ / CH₂Cl₂ / 20 °C

5.1: 97 percent / POCl₃; 2,4,6-collidine / acetonitrile / 3 h / 85 °C

6.1: LiAlH₄; Me₃Al / tetrahydrofuran; hexane / -78 - 20 °C

7.1: NaH / tetrahydrofuran

7.2: 85 percent / tetrahydrofuran / -78 °C

8.1: 93 percent / NEt₃ / CH₂Cl₂ / 20 °C

9.1: 89 percent / I₂; PhI(O₂CCF₃)2 / CH₂Cl₂ / -10 - 0 °C

10.1: 99 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

11.1: NaH / tetrahydrofuran / 21 h / 0 - 20 °C

11.2: 83 percent / BH₃*THF / tetrahydrofuran / 0.67 h / 20 °C

With 2,4,6-trimethyl-pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; iodine; trimethylaluminum; sodium hydride; magnesium; ethylene dibromide; triethylamine; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene; hydrazine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetonitrile; 1.1: Metallation / 1.2: Ring cleavage / 2.1: Mitsunobu reaction / 3.1: Hydrazinolysis / 4.1: Acetylation / 5.1: Bischler-Napieralski cyclization / 6.1: Reduction / 7.1: Metallation / 7.2: Etherification / 8.1: Tosylation / 9.1: Iodination / 10.1: Desilylation / 11.1: Diphenylphosphanylation / 11.2: Reduction;

DOI:10.1002/(SICI)1521-3773(19991203)38:23<3530::AID-ANIE3530>3.0.CO;2-W

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → C32H33INO5PS (257299-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 93 percent / NEt₃ / CH₂Cl₂ / 20 °C

2.1: 89 percent / I₂; PhI(O₂CCF₃)2 / CH₂Cl₂ / -10 - 0 °C

3.1: 99 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

4.1: NaH / tetrahydrofuran / 21 h / 0 - 20 °C

4.2: 83 percent / BH₃*THF / tetrahydrofuran / 0.67 h / 20 °C

With tetrabutyl ammonium fluoride; iodine; sodium hydride; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; dichloromethane; 1.1: Tosylation / 2.1: Iodination / 3.1: Desilylation / 4.1: Diphenylphosphanylation / 4.2: Reduction;

DOI:10.1002/(SICI)1521-3773(19991203)38:23<3530::AID-ANIE3530>3.0.CO;2-W

Reference yield:

2-(tert-butyl-dimethyl-silanyloxy)-1-(3,5-dimethoxy-benzyl)-ethylamine (228704-10-7) → C32H33INO5PS (257299-99-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 99 percent / NEt₃ / CH₂Cl₂ / 20 °C

2.1: 97 percent / POCl₃; 2,4,6-collidine / acetonitrile / 3 h / 85 °C

3.1: LiAlH₄; Me₃Al / tetrahydrofuran; hexane / -78 - 20 °C

4.1: NaH / tetrahydrofuran

4.2: 85 percent / tetrahydrofuran / -78 °C

5.1: 93 percent / NEt₃ / CH₂Cl₂ / 20 °C

6.1: 89 percent / I₂; PhI(O₂CCF₃)2 / CH₂Cl₂ / -10 - 0 °C

7.1: 99 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

8.1: NaH / tetrahydrofuran / 21 h / 0 - 20 °C

8.2: 83 percent / BH₃*THF / tetrahydrofuran / 0.67 h / 20 °C

With 2,4,6-trimethyl-pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; iodine; trimethylaluminum; sodium hydride; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1.1: Acetylation / 2.1: Bischler-Napieralski cyclization / 3.1: Reduction / 4.1: Metallation / 4.2: Etherification / 5.1: Tosylation / 6.1: Iodination / 7.1: Desilylation / 8.1: Diphenylphosphanylation / 8.2: Reduction;

DOI:10.1002/(SICI)1521-3773(19991203)38:23<3530::AID-ANIE3530>3.0.CO;2-W

upstream raw materials:

1-chloro-3,5-dimethoxybenzene

p-toluenesulfonyl chloride

2-(tert-butyl-dimethyl-silanyloxy)-1-(3,5-dimethoxy-benzyl)-ethylamine

((1R,3S)-6,8-Dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol