3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

Base Information

Chemical Name:3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde
CAS No.:958457-39-1
Molecular Formula:C₂₀H₁₃ClF₃NO₄
Molecular Weight:423.776
Hs Code.:

Synonyms:3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

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Chemical Property of 3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

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Technology Process of 3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

There total 12 articles about 3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3-chloro-2-hydroxymethyl-6-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

: 958457-39-1
3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 958457-41-5
(4-(4-(trifluoromethoxy)phenoxy)phenyl)boronic acid

: 958457-39-1
3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

2: ammonia / ethanol; water / 140 °C

3: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; In methanol; ethanol; dichloromethane; water; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 873203-36-2
1-bromo-4-[4-(trifluoromethoxy)phenoxy]benzene

: 958457-39-1
3-chloro-6-methyl-4-oxo-3-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-1,4-dihydro-2-pyridinecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: hydrogenchloride / water / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

4: ammonia / ethanol; water / 140 °C

5: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.07.044