{1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

Base Information

Chemical Name:{1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol
CAS No.:133363-16-3
Molecular Formula:C₄₀H₄₆O₆Si
Molecular Weight:650.887
Hs Code.:

Synonyms:{1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

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Chemical Property of {1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

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Technology Process of {1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

There total 12 articles about {1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((S)-2-{4-Benzyloxy-3-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-methoxy-5-methoxymethoxy-naphthalen-2-yl}-1-methyl-ethoxy)-tert-butyl-diphenyl-silane

: 133363-16-3
{1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.0833333h; Yield given;
DOI:10.1016/S0040-4039(00)92105-1

Reference yield:

: 13321-73-8
2-bromo-1,5-dimethoxy-3-methylbenzene

: 133363-16-3
{1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) n-BuLi / 1.) Et₂O, 0 deg, 30 min

2: (COCl)2 / 0 - 20 °C

3: pyridine

4: BBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

5: NaH / dimethylformamide

6: 1.) LDA / 1.) THF, -78 deg, 10 min

7: DDQ / dioxane / 0.17 h / 60 °C

8: K₂CO₃ / dimethylsulfoxide / 16 h / 20 °C

9: LAH / tetrahydrofuran / 1 h / 0 °C

10: pyridine / 24 h

11: imidazole / dimethylformamide / 16 h / 0 - 20 °C

12: TsOH / CH₂Cl₂; methanol / 0.08 h

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; boron tribromide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)92105-1

Reference yield:

: 3686-57-5
2,4-dimethoxy-6-methylbenzoic acid

: 133363-16-3
{1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol

Guidance literature:: Multi-step reaction with 11 steps

1: (COCl)2 / 0 - 20 °C

2: pyridine

3: BBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

4: NaH / dimethylformamide

5: 1.) LDA / 1.) THF, -78 deg, 10 min

6: DDQ / dioxane / 0.17 h / 60 °C

7: K₂CO₃ / dimethylsulfoxide / 16 h / 20 °C

8: LAH / tetrahydrofuran / 1 h / 0 °C

9: pyridine / 24 h

10: imidazole / dimethylformamide / 16 h / 0 - 20 °C

11: TsOH / CH₂Cl₂; methanol / 0.08 h

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; boron tribromide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)92105-1