N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

Base Information

Chemical Name:N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide
CAS No.:1436420-53-9
Molecular Formula:C₂₂H₂₄ClF₃N₄O
Molecular Weight:452.907
Hs Code.:

Synonyms:N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

Chemical Property:

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Technology Process of N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

There total 5 articles about N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂ClF₃N₄O₃

: 1436420-53-9
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 5h;

Reference yield:

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 1436420-53-9
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 5 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436420-53-9
N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)isoindoline-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 5 h

With hydrogenchloride; ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol;