((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

Base Information

Chemical Name:((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester
CAS No.:240407-02-7
Molecular Formula:C₃₃H₅₂O₄Si
Molecular Weight:540.859
Hs Code.:

((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

Synonyms:((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

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Chemical Property of ((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

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Technology Process of ((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

There total 6 articles about ((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 240407-01-6
((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid

: 240406-99-9
[(3R,4S)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enyl]-methanol

: 240407-02-7
((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0040-4039(99)00828-X

Reference yield:

: 13746-43-5
(R)-2,2,4-trimethyl-cyclohex-3-enecarboxylic acid

: 240407-02-7
((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2

3: Ag₂O

4: 66 percent / EDCI; DMAP / CH₂Cl₂

With dmap; oxalyl dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; silver(l) oxide; In dichloromethane; 1: Chlorination / 2: Alkylation / 3: Arndt-Eistert homologation / 4: Esterification;
DOI:10.1016/S0040-4039(99)00828-X

Reference yield:

: 188052-34-8
((1R,6S)-6-Benzyloxy-3-chloromethyl-1-methyl-cyclohex-2-enylmethoxy)-tert-butyl-dimethyl-silane

: 240407-02-7
((S)-2,2,4-Trimethyl-cyclohex-3-enyl)-acetic acid (3R,4S)-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohex-1-enylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMSO; NaHCO₃ / toluene

2: NaBH₄ / methanol

3: 66 percent / EDCI; DMAP / CH₂Cl₂

With dmap; sodium tetrahydroborate; sodium hydrogencarbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; toluene; 1: Kornblum oxidation / 2: Reduction / 3: Esterification;
DOI:10.1016/S0040-4039(99)00828-X