Technology Process of 5-(2-chlorophenyl)-2,4-dimethoxypyrimidine
There total 1 articles about 5-(2-chlorophenyl)-2,4-dimethoxypyrimidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate; triphenylphosphine; palladium dichloride;
In
1,2-dimethoxyethane; ethanol; water;
for 24h;
Inert atmosphere;
Reflux;
DOI:10.1002/chem.201300552
- Guidance literature:
-
5-(2-chlorophenyl)-2,4-dimethoxypyrimidine;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 2h;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran; hexane;
Inert atmosphere;
DOI:10.1002/chem.201300552
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium; dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc / tetrahydrofuran; hexane / 2 h / 20 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: cesium fluoride; bis(dibenzylideneacetone)-palladium(0); triphenylphosphine / 1,4-dioxane / 18 h / 105 °C / Inert atmosphere
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; triphenylphosphine; cesium fluoride; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; 1,4-dioxane; hexane;
2.1: |Suzuki Coupling;
DOI:10.1002/chem.201300552
