(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

Base Information

Chemical Name:(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol
CAS No.:201284-30-2
Molecular Formula:C₃₀H₄₈O₅Si
Molecular Weight:516.794
Hs Code.:

Synonyms:(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

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Chemical Property of (5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

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Technology Process of (5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

There total 4 articles about (5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 201284-46-0
(E)-(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-hept-2-en-1-ol

: 201284-30-2
(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1248/cpb.45.2113

Reference yield:

: 163275-31-8
(3R,4S)-4-Benzyloxy-5-(tert-butyldimethylsiloxy)-3-(p-methoxybenzyloxy)-2,2-dimethylpentanal

: 201284-30-2
(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 2.) THF

2: 93 percent / DIBAL / CH₂Cl₂

3: 86 percent / H₂ / Pd/C / ethyl acetate

With hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1248/cpb.45.2113

Reference yield:

: 201284-14-2
(3R,4S)-4-Benzyloxy-5-(tert-butyldimethylsiloxy)-3-(p-methoxybenzyloxy)-2,2-dimethylpentanol

: 201284-30-2
(5R,6S)-6-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,4-dimethyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: 1.) NaH / 1.) THF, 2.) THF

3: 93 percent / DIBAL / CH₂Cl₂

4: 86 percent / H₂ / Pd/C / ethyl acetate

With oxalyl dichloride; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1248/cpb.45.2113