3-Pyridinamine, 4-methyl-6-(methylthio)-

Base Information

• Chemical Name: 3-Pyridinamine, 4-methyl-6-(methylthio)-
• CAS No.: 225942-10-9
• Molecular Formula: C₇H₁₀N₂S
• Molecular Weight: 154.236
• Mol file: 225942-10-9.mol

Synonyms:5-Amino-4-methyl-2-methylthiopyridine

Chemical Property of 3-Pyridinamine, 4-methyl-6-(methylthio)-

Chemical Property:

• PSA: 64.21000
• LogP: 2.27530

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-6-(methylthio)pyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinamine, 4-methyl-6-(methylthio)-

There total 1 articles about 3-Pyridinamine, 4-methyl-6-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-methyl-2-methylsulfanyl-5-nitro-pyridine (66665-86-9) → 5-amino-4-methyl-2-methylthiopyridine (225942-10-9)

Guidance literature:

4-methyl-2-methylsulfanyl-5-nitro-pyridine; With hydrogenchloride; acetic acid; zinc; In water; at 0 - 20 ℃; for 0.583333h;

With sodium hydrogencarbonate; In water;

Reference yield:

5-amino-4-methyl-2-methylthiopyridine (225942-10-9) → tert-butyl {1-[2-(6-ethoxy-3-fluoro-8-methyl-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]oct-4-yl}carbamate

Guidance literature:

Multi-step reaction with 9 steps

1.1: toluene / 1 h / Reflux

2.1: diphenylether / 0.13 h / 260 °C

3.1: phosphorus tribromide / water; N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

5.1: 4-methyl-morpholine / 1,2-dichloro-ethane / 0.25 h / 20 °C

5.2: 1.75 h / Reflux

5.3: Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: nitrosonium tetrafluoroborate / tetrahydrofuran / 0.83 h / 0 °C

8.1: Oxone / tetrahydrofuran; water; methanol / 3 h / 20 °C

9.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

9.2: 12 h / 70 °C

With 4-methyl-morpholine; Oxone; 9-borabicyclo[3.3.1]nonane dimer; water; phosphorus tribromide; nitrosonium tetrafluoroborate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diphenylether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

5-amino-4-methyl-2-methylthiopyridine (225942-10-9) → 1-(2-(6-ethoxy-3-fluoro-8-methyl-1,5-naphthyridin-4-yl)ethyl)-2-oxabicyclo[2.2.2]octan-4-amine

Guidance literature:

Multi-step reaction with 10 steps

1.1: toluene / 1 h / Reflux

2.1: diphenylether / 0.13 h / 260 °C

3.1: phosphorus tribromide / water; N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

5.1: 4-methyl-morpholine / 1,2-dichloro-ethane / 0.25 h / 20 °C

5.2: 1.75 h / Reflux

5.3: Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: nitrosonium tetrafluoroborate / tetrahydrofuran / 0.83 h / 0 °C

8.1: Oxone / tetrahydrofuran; water; methanol / 3 h / 20 °C

9.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

9.2: 12 h / 70 °C

10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With 4-methyl-morpholine; Oxone; 9-borabicyclo[3.3.1]nonane dimer; water; phosphorus tribromide; nitrosonium tetrafluoroborate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diphenylether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-methyl-2-methylsulfanyl-5-nitro-pyridine

Refernces