{2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

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Chemical Name:{2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester
CAS No.:148549-88-6
Molecular Formula:C₃₀H₃₃ClN₄O₃
Molecular Weight:533.07
Hs Code.:

Synonyms:{2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

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Chemical Property of {2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

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Technology Process of {2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

There total 8 articles about {2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 148549-88-6
{2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SO₂Cl₂, 2.) n-Bu₄NBr / 1.) CHCl₃, reflux, 3 h, 2.) CHCl₃, H₂O, RT, 2 h

2: 6 N aq. HCl / 3 h / Heating

3: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

4: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

5: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With hydrogenchloride; dmap; sulfuryl dichloride; tetrabutylammomium bromide; hydrogen; pivaloyl chloride; trimethyl orthoformate; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007

Reference yield:

: 114771-99-2
2-Butyl-4-chloro-5-(cyanomethyl]-l-[(4-nitrophenyl)-methyl]imidazole

: 148549-88-6
{2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 6 N aq. HCl / 3 h / Heating

2: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

3: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

4: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With hydrogenchloride; dmap; hydrogen; pivaloyl chloride; trimethyl orthoformate; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007

Reference yield:

: 114772-03-1
EXP 9993

: 148549-88-6
{2-Butyl-5-chloro-3-[4-((S)-3-phenyl-2-pyrrol-1-yl-propionylamino)-benzyl]-3H-imidazol-4-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

2: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

3: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With hydrogenchloride; dmap; hydrogen; pivaloyl chloride; trimethyl orthoformate; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007