(S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HYDROCHLORIDE
• CAS No.: 225918-58-1
• Molecular Formula: C8H8 Cl N O2 . Cl H
• Molecular Weight: 222.071
• Hs Code.: 2922499990
• Mol file: 225918-58-1.mol

Synonyms:Benzeneaceticacid, a-amino-2-chloro-, hydrochloride,(aS)- (9CI)

Chemical Property of (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 63.32000
• LogP: 2.92670

Purity/Quality:

99% ^*data from raw suppliers

(S)-Amino-(2-chloro-phenyl)-aceticacidhydrochloride 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HYDROCHLORIDE

There total 3 articles about (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride (1430061-09-8) → (2S)-2-(2-chlorophenyl)glycine hydrochloride (225918-58-1,1259983-42-0)

Guidance literature:

With hydrogenchloride; water; In diethyl ether; at 90 ℃; for 4h;

DOI:10.1055/s-0032-1316852

Reference yield:

(S)-α-(2-chlorophenyl)-α-[(diphenylmethyl)amino]acetonitrile (225918-54-7) → (2S)-2-(2-chlorophenyl)glycine hydrochloride (225918-58-1,1259983-42-0)

Guidance literature:

With hydrogenchloride; water; trifluoroacetic acid; at 80 ℃; for 18h;

DOI:10.1016/j.tet.2009.04.098

Reference yield:

2-chloro-benzaldehyde (89-98-5) → (2S)-2-(2-chlorophenyl)glycine hydrochloride (225918-58-1,1259983-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; water / 16 h / 25 - 30 °C

2: water; hydrogenchloride / diethyl ether / 4 h / 90 °C

With hydrogenchloride; water; In methanol; diethyl ether; water;

DOI:10.1055/s-0032-1316852

upstream raw materials:

(S)-α-(2-chlorophenyl)-α-[(diphenylmethyl)amino]acetonitrile

2-chloro-benzaldehyde

(2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile hydrochloride

Downstream raw materials:

N-Boc-(S)-2-chlorophenylglycine

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

(S)-(+)-clopidogrel

(S)-(+)-clopidogrel bisulfate