N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

Base Information

Chemical Name:N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide
CAS No.:1073488-54-6
Molecular Formula:C₁₈H₁₈Cl₂N₄O
Molecular Weight:377.273
Hs Code.:

Synonyms:N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

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Chemical Property of N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

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Technology Process of N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

There total 1 articles about N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 72934-37-3
3-(4-chlorophenyl)-1-cyclopropanecarboxylic acid

: 66597-78-2
1-chloro-4-hydrazino-5,6,7,8-tetrahydrophthalazine

: 1073488-54-6
N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

Guidance literature:: 3-(4-chlorophenyl)-1-cyclopropanecarboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

1-chloro-4-hydrazino-5,6,7,8-tetrahydrophthalazine; In tetrahydrofuran; for 1.83333h;

Reference yield: 57.0%

: 1073488-54-6
N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

: 1073488-56-8
6-chloro-3-(1-(4-chlorophenyl)cyclopropyl)-7,8,9,10-tetrahydro-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; triethylphosphine; In tetrahydrofuran; tetrachloromethane; at 0 ℃; for 0.666667h;

Reference yield:

: 1073488-54-6
N'-(4-chloro-5,6,7,8-tetrahydrophthalazin-1-yl)-1-(4-chlorophenyl)cyclopropanecarbohydrazide

: 1073488-48-8
3-(1-(4-chlorophenyl)cyclopropyl)-7,8,9,10-tetrahydro-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; triethylphosphine / tetrahydrofuran; tetrachloromethane / 0.67 h / 0 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 15 h / 760.05 Torr

With hydrogen; N-ethyl-N,N-diisopropylamine; triethylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane;