Carbamic acid, [(1R)-3-oxocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(1R)-3-oxocyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 225641-86-1
• Molecular Formula: C10H17 N O3
• Molecular Weight: 199.24688
• Mol file: 225641-86-1.mol

Synonyms:Carbamicacid, [(1R)-3-oxocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [(1R)-3-oxocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 58.89000
• LogP: 1.83710
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-(Boc-amino)cyclopentanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1R)-3-oxocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

There total 2 articles about Carbamic acid, [(1R)-3-oxocyclopentyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl ((1R)-3-hydroxycyclopentyl)carbamate (1154870-59-3,207729-04-2) → tert-butyl (R)-(3-oxocyclopentyl)carbamate (225641-86-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield: 84.0%

tert-butyl N-[(1R,3S)-3-hydroxycyclopentyl]carbamate (225641-84-9,1154870-59-3,207729-04-2) → tert-butyl (R)-(3-oxocyclopentyl)carbamate (225641-86-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

Reference yield:

N-methyl-4-(trifluoromethyl)aniline (22864-65-9) + tert-butyl (R)-(3-oxocyclopentyl)carbamate (225641-86-1) → tert-butyl ((1R,3R)-3-(methyl(4-(trifluoromethyl)phenyl)amino)cyclopentyl)carbamate + tert-butyl ((1R,3S)-3-(methyl(4-(trifluoromethyl)phenyl)amino)cyclopentyl)carbamate

Guidance literature:

N-methyl-4-(trifluoromethyl)aniline; tert-butyl (R)-(3-oxocyclopentyl)carbamate; With acetic acid; In methanol; at 20 ℃; for 0.333333h;

With triethylsilane; indium(III) chloride; In methanol; at 20 ℃; for 12h; Overall yield = 52 percent; Overall yield = 726 mg;

upstream raw materials:

tert-butyl N-[(1R,3S)-3-hydroxycyclopentyl]carbamate

tert-butyl ((1R)-3-hydroxycyclopentyl)carbamate

Downstream raw materials:

1-((1S,3R)-3-Amino-cyclopentyl)-4-phenyl-piperidine-4-carbonitrile

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