2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

Base Information

Chemical Name:2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol
CAS No.:949886-87-7
Molecular Formula:C₃₀H₂₈F₂O₄
Molecular Weight:490.547
Hs Code.:

Synonyms:2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

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Chemical Property of 2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

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Technology Process of 2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

There total 6 articles about 2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,3,4-tri-O-benzyl-6,6,7,7-tetradehydro-6,7,8-trideoxy-D-galacto-octono-1,5-lactone

: 75-61-6
dibromodifluoromethane

: 949886-87-7
2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -10 - 20 ℃; for 3h;
DOI:10.1016/j.carres.2007.05.021

Reference yield:

: 949886-85-5
para-methoxyphenyl 2,3,4-tri-O-benzyl-6,6,7,7-tetradehydro-6,7,8-trideoxy-β-D-galacto-octopyranoside

: 949886-87-7
2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / ammonium cerium(IV) nitrate / H₂O; acetone / 0.08 h / 20 °C

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 20 °C

3: 155.9 mg / HMPT / tetrahydrofuran / 3 h / -10 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; oxalyl dichloride; ammonium cerium(IV) nitrate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone; 2: Swern oxidation;
DOI:10.1016/j.carres.2007.05.021

Reference yield:

: 2,3,4-tri-O-benzyl-6,6,7,7-tetradehydro-6,7,8-trideoxy-α-β-D-galacto-octopyranose

: 949886-87-7
2,6-anhydro-3,4,5-tri-O-benzyl-7,7,8,8-tetradehydro-1,7,8,9-tetradeoxy-1,1-difluoro-D-galacto-non-1-enitol

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 20 °C

2: 155.9 mg / HMPT / tetrahydrofuran / 3 h / -10 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1: Swern oxidation;
DOI:10.1016/j.carres.2007.05.021