(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

Base Information

Chemical Name:(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid
CAS No.:1455088-41-1
Molecular Formula:C₂₂H₁₉N₃O₅
Molecular Weight:405.41
Hs Code.:

Synonyms:(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

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Chemical Property of (2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

Chemical Property:

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Technology Process of (2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

There total 4 articles about (2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455093-20-5
(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid tert-butyl ester

: 1455088-41-1
(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylbutyrate

: 1455088-41-1
(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20% palladium hydroxide-activated charcoal; hydrogen / 48 h / 760.05 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

2.2: 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With 20% palladium hydroxide-activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1455091-23-2
1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 1455088-41-1
(2S,3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; tetrahydrofuran; water / 5 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

2.2: 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;