2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

Base Information

Chemical Name:2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone
CAS No.:1190643-95-8
Molecular Formula:C₂₅H₂₈ClN₃O₂
Molecular Weight:437.969
Hs Code.:

Synonyms:2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

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Chemical Property of 2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

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Technology Process of 2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

There total 6 articles about 2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190643-94-7
4-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-acetyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1190643-95-8
2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

Guidance literature:: With hydrogenchloride; In dichloromethane; isopropyl alcohol; at 20 ℃; for 14h;

Reference yield:

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 1190643-95-8
2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 - 20 °C

2.1: trichlorophosphate / toluene / 8 h / Reflux

3.1: water; hydrogen bromide / 4 h / 120 °C

3.2: pH 10

4.1: potassium carbonate / N,N-dimethyl acetamide / 2 h / Reflux

5.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 14 h / 20 °C

With hydrogenchloride; dmap; water; hydrogen bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol; toluene;

Reference yield:

: 916923-23-4
1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide

: 1190643-95-8
2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / toluene / 8 h / Reflux

2.1: water; hydrogen bromide / 4 h / 120 °C

2.2: pH 10

3.1: potassium carbonate / N,N-dimethyl acetamide / 2 h / Reflux

4.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 14 h / 20 °C

With hydrogenchloride; water; hydrogen bromide; potassium carbonate; trichlorophosphate; In dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol; toluene;