(Z)-3-bromo-3-(p-tolyl)acrylaldehyde

Base Information

• Chemical Name: (Z)-3-bromo-3-(p-tolyl)acrylaldehyde
• CAS No.: 1021942-52-8
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.085
• Mol file: 1021942-52-8.mol

Synonyms:(Z)-3-bromo-3-(p-tolyl)acrylaldehyde

Chemical Property of (Z)-3-bromo-3-(p-tolyl)acrylaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-bromo-3-(p-tolyl)acrylaldehyde

There total 2 articles about (Z)-3-bromo-3-(p-tolyl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one (18103-98-5) → (Z)-3-bromo-3-(p-tolyl)acrylaldehyde (1021942-52-8)

Guidance literature:

3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one; With phosphorus(V) oxybromide; In dichloromethane; for 2h; Reflux;

With water; In tetrahydrofuran; at 20 ℃; diastereoselective reaction;

DOI:10.1016/j.tet.2010.09.080

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + para-methylacetophenone (122-00-9) → (Z)-3-bromo-3-(p-tolyl)acrylaldehyde (1021942-52-8)

Guidance literature:

N,N-dimethyl-formamide; With phosphorus tribromide; In chloroform; cooling;

para-methylacetophenone; In chloroform; at 20 ℃; for 8h;

DOI:10.1021/ol062418t

Reference yield: 92.0%

(Z)-3-bromo-3-(p-tolyl)acrylaldehyde (1021942-52-8) → (Z)-3-bromo-3-(p-tolyl)acrylic acid (1258494-03-9)

Guidance literature:

(Z)-3-bromo-3-(p-tolyl)acrylaldehyde; With sodium chlorite; disodium hydrogen phosphate monohydrate; In water; dimethyl sulfoxide; at 0 - 20 ℃; for 24h;

In water; dimethyl sulfoxide; pH=2; Cooling with ice; Acidic conditions;

DOI:10.1016/j.tet.2010.09.080

upstream raw materials:

N,N-dimethyl-formamide

para-methylacetophenone

3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one

Downstream raw materials:

4-(p-tolyl)quinoline

4,4-dimethyl-3-(4-methylphenyl)-cyclopent-2-en-1-one

4,4-dimethyl-3-p-tolyl-cyclopent-2-enol

3-(p-methylphenyl)isoxazole