(-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol

Base Information

• Chemical Name: (-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol
• CAS No.: 1258965-41-1
• Molecular Formula: C₂₀H₃₂O₃
• Molecular Weight: 320.472
• Mol file: 1258965-41-1.mol

Synonyms:(-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol

Chemical Property of (-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol

There total 1 articles about (-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(-)-(1Z,2S,3S,4S,5S)-1-ethylidene-5-hydroxy-3-((1S)-1-phenylethoxy)-2,4,5-trimethylheptyl benzoate (1258965-40-0) → (-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol (1258965-41-1)

Guidance literature:

(-)-(1Z,2S,3S,4S,5S)-1-ethylidene-5-hydroxy-3-((1S)-1-phenylethoxy)-2,4,5-trimethylheptyl benzoate; With methyllithium lithium bromide; In 1,2-dimethoxyethane; diethyl ether; at -78 ℃; for 5h;

With water; ammonium chloride; at 0 ℃;

DOI:10.1002/anie.201003735

Reference yield: 69.0%

(-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-3,5-dimethyl-4-((1S)-1-phenylethoxy)tetrahydro-2H-pyran-2-ol (1258965-41-1) → (-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-2-methoxy-3,5-dimethyltetrahydro-2H-pyran-4-ol (1258965-42-2)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In methanol; at 20 ℃; for 3h; under 750.075 Torr;

DOI:10.1002/anie.201003735

upstream raw materials:

(-)-(1Z,2S,3S,4S,5S)-1-ethylidene-5-hydroxy-3-((1S)-1-phenylethoxy)-2,4,5-trimethylheptyl benzoate

Downstream raw materials:

(-)-(2R,3S,4S,5R,6S)-2-ethyl-6-isopropyl-2-methoxy-3,5-dimethyltetrahydro-2H-pyran-4-ol