1-BROMONONAFLUOROBUTANE

Base Information

• Chemical Name: 1-BROMONONAFLUOROBUTANE
• CAS No.: 375-48-4
• Molecular Formula: C4Br F9
• Molecular Weight: 298.934
• Hs Code.: 2903799090
• Mol file: 375-48-4.mol

Synonyms:Butane,1-bromononafluoro- (8CI); 1-Bromononafluorobutane; 1-Bromoperfluorobutane;Perfluorobutyl bromide

Chemical Property of 1-BROMONONAFLUOROBUTANE

Chemical Property:

• Boiling Point: 44.8°Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: 1.904g/cm³
• LogP: 3.80700

Purity/Quality:

99% ^*data from raw suppliers

1-Bromononafluorobutane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Uses: 1-Bromononafluorobutane is a useful research chemical, a nonanesthetic polyhalogenated alkanes.

Technology Process of 1-BROMONONAFLUOROBUTANE

There total 3 articles about 1-BROMONONAFLUOROBUTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

polytetrafluoroethylene (116-14-3,82785-14-6) + 1,2-dibromo-1,1,2,2-tetrafluoroethane (124-73-2) → 1-bromopentadecafluoroheptane (375-88-2) + nonafluoro-1-bromobutane (375-48-4) + 1,4-dibromo-1,1,2,2,3,3,4,4-octafluoro-butane (335-48-8) + 1-bromo-1H-undecafluoro-pentane (558-91-8)

Guidance literature:

Further byproducts given;

DOI:10.1021/jo00945a013

Reference yield:

polytetrafluoroethylene (116-14-3,82785-14-6) + 1,2-dibromo-1,1,2,2-tetrafluoroethane (124-73-2) → 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexane (335-56-8) + nonafluoro-1-bromobutane (375-48-4) + 1,4-dibromo-1,1,2,2,3,3,4,4-octafluoro-butane (335-48-8) + 1-bromo-1H-undecafluoro-pentane (558-91-8)

Guidance literature:

Further byproducts given;

DOI:10.1021/jo00945a013

Reference yield:

polytetrafluoroethylene (116-14-3,82785-14-6) + 1,2-dibromo-1,1,2,2-tetrafluoroethane (124-73-2) → nonafluoro-1-bromobutane (375-48-4) + 1,4-dibromo-1,1,2,2,3,3,4,4-octafluoro-butane (335-48-8) + 1-bromo-1H-undecafluoro-pentane (558-91-8) + tetradecafluorohexane (355-42-0)

Guidance literature:

Further byproducts given;

DOI:10.1021/jo00945a013

upstream raw materials:

polytetrafluoroethylene

1,2-dibromo-1,1,2,2-tetrafluoroethane

Downstream raw materials:

1,1,1,2,2,3,3,4,4-nonafluorohexane

1H,1H,2H,2H-perfluoro-n-hexyl bromide

8-bromo-1,1,1,2,2,3,3,4,4-nonafluoro-octane

Refernces

Ruthenium-Catalyzed Site-Selective Trifluoromethylations and (Per)Fluoroalkylations of Anilines and Indoles

10.1002/chem.202001439

The study presents a novel and practical method for ortho-selective C-H perfluoroalkylation, including trifluoromethylations, of anilines and indoles using ruthenium catalysis. The process is significant for the synthesis of various (per)fluoroalkylated building blocks, which are valuable for creating bioactive compounds and materials. The researchers utilized commercially available reagents RI and RfBr, achieving high site selectivity without the need for protecting groups. The methodology is attractive due to the availability and cost of the starting materials, and it offers a mild reaction condition for the direct C-H perfluoroalkylation of anilines. The study also explores the substrate scope and reaction conditions, demonstrating the potential for gram-scale synthesis and the successful application to indoles, providing a pathway to selectively functionalize these important heterocyclic compounds.