Technology Process of 3-hydroxy-3-isopropyl-5-(p-nitrophenyl)-4-pentenoic acid benzyl ester
There total 4 articles about 3-hydroxy-3-isopropyl-5-(p-nitrophenyl)-4-pentenoic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Benzyl acetate;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
Combinatorial reaction / High throughput screening (HTS);
Large scale;
(E)-4-methyl-1-(p-nitrophenyl)-1-penten-3-one;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -65 - -59 ℃;
Combinatorial reaction / High throughput screening (HTS);
Large scale;
With
acetic acid;
In
tetrahydrofuran; methanol; hexane;
at -64 - 28 ℃;
Combinatorial reaction / High throughput screening (HTS);
Large scale;
DOI:10.1021/op000206k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene; tert-butyl methyl ether / Combinatorial reaction / High throughput screening (HTS); Inert atmosphere; Large scale
2.1: pyridine / toluene; tert-butyl methyl ether / 6 h / 85 - 87 °C / Combinatorial reaction / High throughput screening (HTS); Inert atmosphere; Large scale
3.1: n-butyllithium / tetrahydrofuran; hexane / Combinatorial reaction / High throughput screening (HTS); Large scale
3.2: -65 - -59 °C / Combinatorial reaction / High throughput screening (HTS); Large scale
3.3: -64 - 28 °C / Combinatorial reaction / High throughput screening (HTS); Large scale
With
pyridine; n-butyllithium;
In
tetrahydrofuran; hexane; tert-butyl methyl ether; toluene;
DOI:10.1021/op000206k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / toluene; tert-butyl methyl ether / 6 h / 85 - 87 °C / Combinatorial reaction / High throughput screening (HTS); Inert atmosphere; Large scale
2.1: n-butyllithium / tetrahydrofuran; hexane / Combinatorial reaction / High throughput screening (HTS); Large scale
2.2: -65 - -59 °C / Combinatorial reaction / High throughput screening (HTS); Large scale
2.3: -64 - 28 °C / Combinatorial reaction / High throughput screening (HTS); Large scale
With
pyridine; n-butyllithium;
In
tetrahydrofuran; hexane; tert-butyl methyl ether; toluene;
DOI:10.1021/op000206k
