methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate

Base Information

Chemical Name:methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate
CAS No.:869748-83-4
Molecular Formula:C₂₁H₁₆F₃NO₃
Molecular Weight:387.358
Hs Code.:

Synonyms:methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate

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Chemical Property of methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate

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Technology Process of methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate

There total 2 articles about methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 528894-31-7
4-((2,2,2-trifluoroacetamido)methyl)phenylboronic acid

: 33626-98-1
methyl 6-bromo-2-naphthoate

: 869748-83-4
methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate

Guidance literature:: With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 20h; Heating;
DOI:10.1016/j.tetlet.2005.08.151

Reference yield:

: 4-(aminomethyl)phenylboronic acid hydrochloride

: 869748-83-4
methyl 6-[4-(N-trifluoroacetylamino)methylphenyl]-2-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Et₃N / methanol / 43 h

2: 100 percent / KF / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

With potassium fluoride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 2: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1016/j.tetlet.2005.08.151