Pyridin-4-YL(1-trityl-1H-imidazol-4-YL)methanol

Base Information

• Chemical Name: Pyridin-4-YL(1-trityl-1H-imidazol-4-YL)methanol
• CAS No.: 224168-75-6
• Molecular Formula: C28H23 N3 O
• Molecular Weight: 417.51
• DSSTox Substance ID: DTXSID70467106
• Mol file: 224168-75-6.mol

Synonyms:224168-75-6;PYRIDIN-4-YL(1-TRITYL-1H-IMIDAZOL-4-YL)METHANOL;Pyridin-4-yl-(1-tritylimidazol-4-yl)methanol;SCHEMBL845130;DTXSID70467106;WKIHEQYNXPKUBJ-UHFFFAOYSA-N;AB44344;pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methanol;(Pyridin-4-yl)[1-(triphenylmethyl)-1H-imidazol-4-yl]methanol

Chemical Property of Pyridin-4-YL(1-trityl-1H-imidazol-4-YL)methanol

Chemical Property:

• PSA: 50.94000
• LogP: 5.20000
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 417.184112366
• Heavy Atom Count: 32
• Complexity: 514

Purity/Quality:

98%min ^*data from raw suppliers

PYRIDIN-4-YL-(1-TRITYL-1H-IMIDAZOL-4-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)C(C5=CC=NC=C5)O

Technology Process of Pyridin-4-YL(1-trityl-1H-imidazol-4-YL)methanol

There total 2 articles about Pyridin-4-YL(1-trityl-1H-imidazol-4-YL)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-4-carbaldehyde (872-85-5) + ethylmagnesium bromide (925-90-6) + N-trityl-4(5)-iodoimidazole (96797-15-8) → pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)methanol (224168-75-6)

Guidance literature:

ethylmagnesium bromide; N-trityl-4⁽⁵⁾-iodoimidazole; In dichloromethane;

pyridine-4-carbaldehyde; In dichloromethane;

DOI:10.1016/j.bmcl.2005.09.076

Reference yield: 89.0%

pyridine-4-carbaldehyde (872-85-5) + N-trityl-4(5)-iodoimidazole (96797-15-8) → pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)methanol (224168-75-6)

Guidance literature:

N-trityl-4⁽⁵⁾-iodoimidazole; With ethylmagnesium bromide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.75h;

pyridine-4-carbaldehyde; In tetrahydrofuran; dichloromethane; for 16h;

DOI:10.1021/jm030905y

Reference yield: 85.0%

acetic anhydride (108-24-7) + pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)methanol (224168-75-6) → acetic acid pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methyl ester (224168-76-7)

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1016/j.bmcl.2005.09.076

upstream raw materials:

pyridine-4-carbaldehyde

N-trityl-4⁽⁵⁾-iodoimidazole

ethylmagnesium bromide

Downstream raw materials:

acetic acid pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methyl ester