3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 224168-68-7
• Molecular Formula: C10H18 I N O2
• Molecular Weight: 311.163
• Mol file: 224168-68-7.mol

Synonyms:3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property of 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• PSA: 29.54000
• LogP: 2.61630

Purity/Quality:

97% ^*data from raw suppliers

3(S)-Iodomethyl-pyrrolidine-1-carboxylicacidtert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 3 articles about 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate (199174-24-8) → (3S)-iodomethylpyrrolidine-1-carboxylic acid tert-butyl ester (224168-68-7)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; for 15h; Cooling with ice;

Reference yield:

(S)-1-N-boc-β-proline (140148-70-5) → (3S)-iodomethylpyrrolidine-1-carboxylic acid tert-butyl ester (224168-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 0 - 20 °C

1.2: 0 °C

2.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 3 h / 70 °C

With 1H-imidazole; dimethylsulfide borane complex; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

→ (3S)-iodomethylpyrrolidine-1-carboxylic acid tert-butyl ester (224168-68-7)

Guidance literature:

upstream raw materials:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

(S)-1-N-boc-β-proline