2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

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Chemical Name:2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine
CAS No.:1004763-14-7
Molecular Formula:C₂₁H₂₉N₃OS
Molecular Weight:371.547
Hs Code.:

Synonyms:2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

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Chemical Property of 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

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Technology Process of 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

There total 9 articles about 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1334179-67-7
C₂₈H₃₅N₃O₃S₂

: 1004763-14-7
2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

Guidance literature:: With hydrogen bromide; In methoxybenzene; at 100 ℃; for 48h;
DOI:10.1002/cmdc.201100248

Reference yield: 16.0%

: 2-[4-(3-chloropropoxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

: 765-38-8
2-methyl-1-pyrrolidine

: 1004763-14-7
2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

Guidance literature:: In ethyl acetate; at 95 ℃;

Reference yield:

: 911134-67-3
4-(3-chloropropoxy)benzenecarbothioamide

: 1004763-14-7
2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / acetonitrile / 20 h / 90 °C

2: ethanol / 65 h / 65 °C

3: hydrogen bromide / methoxybenzene / 48 h / 100 °C

With hydrogen bromide; potassium carbonate; sodium iodide; In ethanol; methoxybenzene; acetonitrile; 2: Hantzsch condensation;
DOI:10.1002/cmdc.201100248