4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Base Information

Chemical Name:4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate
CAS No.:85768-46-3
Molecular Formula:C₃₂H₄₀Cl₂N₂O₈SSi
Molecular Weight:711.736
Hs Code.:

4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Synonyms:4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

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Chemical Property of 4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

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Technology Process of 4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

There total 5 articles about 4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 85768-31-6
4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio propenoate

: 85768-46-3
4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Guidance literature:: With chlorine; In chloroform; at -40 ℃;
DOI:10.1039/c39830001005

Reference yield:

: 937-64-4
4-chlorophenyl chlorothionoformate

: 85768-46-3
4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) base, 2.) LiN(SiMe₃)2 / 2.) -78 deg C to room temp.

2: 50 percent / -40 - 20 °C

3: 67 percent / Cl₂ / CHCl₃ / -40 °C

With chlorine; lithium hexamethyldisilazane; In chloroform;
DOI:10.1039/c39830001005

Reference yield:

: 85768-12-3
4-nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-ethylthio-azetidin-2-on-1-yl]-acetate

: 85768-46-3
4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) base, 2.) LiN(SiMe₃)2 / 2.) -78 deg C to room temp.

2: 50 percent / -40 - 20 °C

3: 67 percent / Cl₂ / CHCl₃ / -40 °C

With chlorine; lithium hexamethyldisilazane; In chloroform;
DOI:10.1039/c39830001005