3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine

Base Information

Chemical Name:3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine
CAS No.:76969-95-4
Molecular Formula:C₁₂H₇F₃N₄
Molecular Weight:264.21
Hs Code.:
ChEMBL ID:CHEMBL156241
DSSTox Substance ID:DTXSID801184667
Nikkaji Number:J3.412.885E
Wikidata:Q107967174

Synonyms:6-Phenyl-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazine;3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine;CHEMBL156241;SCHEMBL11397300;DTXSID801184667;76969-95-4

Suppliers and Price of 3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:264.06228073
Heavy Atom Count:19
Complexity:317

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NN3C(=NN=C3C(F)(F)F)C=C2

Technology Process of 3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine

There total 3 articles about 3-(Trifluoromethyl)-6-phenyl-1,2,4-triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 38956-80-8
3-hydrazino-6-phenylpyridazine

: 407-25-0
trifluoroacetic anhydride

: 76969-95-4
6-phenyl-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine

Guidance literature:: With pyridine; for 6h; Heating;
DOI:10.1021/jm00137a020

Reference yield: 24.0%

: 40971-95-7
6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

: 98-80-6
phenylboronic acid

: 76969-95-4
6-phenyl-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 120 ℃; for 2h; Sealed tube; Microwave irradiation;
DOI:10.1039/c4md00007b